Read more: The Advantages of Milk Thistle. The recommended dose is 4.5 grams per day for a 500 kg horse. The University of Texas Health Science Center at San Antonio published this study. Horses that tend to be overweight or those with equine metabolic syndrome (EMS) might have excess fat deposits in the liver which can negatively affect its function. Although more comprehensive studies are needed, there is evidence that milk thistle can be used to treat liver problems in dogs and cats. Most of what is known about how these compounds support liver health is based on studies in isolated cells or in animal models. 2007;6(2):158-166. Overall, the majority of patients tolerate even high doses of milk thistle; as with most herbs, adverse effects typically involve gastrointestinal upset. It is metabolized by the pathways in the liver that are activated by compounds found in milk thistle extract; giving these at the same time might make metronidazole less effective. 4. “There are no drugs to improve liver function,” she says. Despite this, horses that are otherwise healthy and young can show signs of liver damage. Dr. Priska Darani has had a lifelong passion for understanding how diet regulates metabolism and contributes to health in both humans and animals. Malewicz B, Wang Z, Jiang C, et al. Key findings of the study included: These positive results add to the overall body of evidence-based medicine on the role of nutritional supplements in equine medicine. It can perform adequately with as much as 80% of its function impaired. Tuesday                       7:30 am - 5:30 pm Both milk thistle and silymarin also neutralized LPS, but less than polymixin B. Silymarin was much more effective than milk thistle and closer to polymixin B in its ability to neutralize LPS. Some of these quality issues, says Raditic, can include heavy metal contamination, possible allergic reaction to fillers and mis-identification of herbs.One sign that a brand adheres to high quality standards is membership to National Animal Supplement Council. Side effects include mild gastrointestinal distress in high doses. The transition to fresh pasture in the springtime comes with many changes like a higher sugar intake and increased exercise that might strain liver function. Studies show that it’s safe when taken for up to 41 months. 12. Follow the recommendations provided by the manufacturer of the product you are using or seek guidance from a veterinarian or qualified equine nutritionist. 2007;6(2):104-109. Bulk milk thistle powder can be given directly as a powder or brewed into a tea to pour over the feed. For Equine Use Only. 2. Foods such as yogurt and…, Just like people, dogs experience stress for a number of reasons. Unable to find a well-formulated supplement at a fair price, he designed his own balanced mineral & vitamin premix. A blood test might also show elevated levels of liver enzymes indicating liver damage including alkaline phosphatase (ALP), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT), glutamate dehydrogenase (GLDH) and sorbitol dehydrogenase (SDH). It's what gives curry its distinct flavor, as well as its yellow color. Side effects are common for any medication, including OTC and prescription drugs. Milk thistle also serves as a liver detoxifier. [3], Milk thistle seeds contain numerous bioactive compounds and phytonutrients that are thought to have beneficial effects. for OMAFRA-funded research on how altering the amino acid balance of lactating cow rations can affect milk production and composition. Select one or more newsletters to continue. Turmeric, also known as Curcuma longa, is commonly used as an ingredient in cooking. Kroll DJ, Shaw KS, and Oberlies NH. You will receive mail with link to set new password. CAUTIONS: Safe use in pregnant animals or animals intended for breeding has not been proven. Potential side effects of milk thistle include: Stomach problems (gas, diarrhea, nausea, vomiting, etc.) More research in horses is needed to fully evaluate these claims. Milk thistle is beneficial and useful for curing many diseases and its properties have been highly appreciated, but over consumption of anything is harmful and the same goes for milk thistle. Silymarin are flavonolignans with antioxidant, antiinflammatory and immunomodulating properties. Key findings of the study included: This can be provided as dried powdered added to the feed or as brewed tea poured over the feed. Milk thistle (Silybum marianum) is a spiny, purple-colored flowering herb native to the Mediterranean and North Africa, but it is now commonly grown in North America. Horses being treated for Lyme disease or Equine Protozoal Myeloencephalitis (EPM) may also benefit from using this supplement. [9]. Integrative Cancer Therapies. Silibinin efficacy against human hepatocellular carcinoma. Fairview, TN 37062 | (615) 799-7981 | All Rights Reserved, Discover The Health Benefits of Shiitake Mushroom Supplements, Top 5 Reasons To Give The Best Probiotics For Cats and Dogs, How Melatonin for Dogs Promotes Relaxation, What you Need to Know About Digestive Enzymes for Dogs. Integrative Cancer Therapies. For Equine Use Only. Speak with your veterinarian about treatment options for these conditions and whether this product or any other supplement should be given at the same time. Horses that have consumed these poisonous plants should be closely monitored for signs of liver damage. Increase the number of meals per day to spread out the feed over multiple meals. Integrative Cancer Therapies. Milk thistle is primarily known for its hepatoprotective effects, meaning it can protect liver tissue from damage and support the function of the liver.Because the liver affects so many physiological processes in the horse’s body, boosting the function of this organ can have wide-ranging benefits for your horse’s health. This will also help minimize large spikes in nutrients reaching the liver after each meal, which will make it easier to metabolize these nutrients without overworking liver cells. 3. Van Erp NPH, Baker SD, Zhao M et al. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. “We think it acts as an antioxidant—an anti-inflammatory agent that may help the liver to heal when it is diseased,” says Donna Raditic, a diplomat of the American College of Veterinary Nutrition. Meeting the horse’s dietary protein requirement without exceeding it will help to not overburden the liver. It is a flavonolignan (a type flavonoid) that acts primarily as an antioxidant to protect cells from dangerous by-products of metabolism, known as free radicals. Lasering in on a better approach for BOAS patients, Abuse: What veterinarians should know, what they can do, Surviving a pandemic as a veterinary professional, New resource keeps COVID out of the workplace, Parvo cases jump a whopping 70 percent during COVID, Ready to reopen? Varzi HN, Esmailzadeh S, Morovvati H, et al. Malewicz B, Wang Z, Jiang C, et al. Milk Thistle supplementation is generally well tolerated in horses and unlikely to result in adverse effects. Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies.