It is also used in organic synthesis as an oxidising agent of moderate strength. Procedure excerpt: To a suspension of H5IO6 (159 mg, 0.698 mmol) in ACN was added CrO3 (0.6 mg, 0.0061 mmol), and the mixture was stirred at RT for 30 min. The method can be used on frozen or paraffin sections and is useful as a reaction for carbohydrates of tissues: glycogen (in paraffin section only), mucin, basement membrane, reticulin, the colloid of the pituitary stalk and thyroid, some of the acidophile cells of the human anterior hypophysis, the granular cells of the renal arteriole, etc. The histochemical uses of the periodic-acid-Schiff's reagent (PAS) need careful control because of the possibility of attachment of iodate or periodate to tissue constitutents, producing a recoloration of the Schiff's reagent. Selective oxidising agent for the planarization of metal conductive layers in silicon chips. When concentrated, orthoperiodic acid, H 5 IO 6, exists in total; this dissociates into hydronium and orthoperiodate (IO 6 5 −) ions in dilute aqueous solution. This can be useful in determining the structure of carbohydrates. Green Stone Swiss Co ., ltd E-mail: sales@chemical-reagent.com. We use cookies to improve your website experience. When more concentrated, orthoperiodic acid, H5IO6, is formed; this dissociates into hydronium and orthoperiodate (IO65−) ions. The mixture was cooled . UK, Accrington site public safety information, Innovative new chemistries for energy capture and storage under development, High purity purification absorbents for hydrocarbon streams under development, Selective oxidising agent for the stripping of polymeric stencils from silk screens. Contact us . Periodic acid is used in organic chemistry for structural analysis. In abnormal tissues, it colors many of the “hyaline” materials— amyloid infiltrations, arteriolosclerotic hyaline, colloid droplets, mitotic figures, etc. Periodic acid will cleave vicinal diols into two aldehyde or ketone fragments. Registered in England & Wales No. Whenever possible the positive reacting material should be further identified by other methods since Lison showed other substances besides aldehydes can recolorize SchifFs reagent. By closing this message, you are consenting to our use of cookies. Periodic acid, or iodic(VII) acid is an oxoacid of iodine having chemical formula HIO4 or H5IO6. Periodate is part of a series of oxyacids in which iodine can assume oxidation states of −1, +1, +3, +5, or +7. . It is also significant in life science applications as the Periodic Acid-Schiff reaction for the analysis of intracellular polysaccharides like glycogen, starch and cellulose. Metaperiodates have solubilities and chemical properties similar to perchlorates (similar but larger ion size) though they are less oxidizing than perchlorates. Periodic acid is used in organic chemistry for structural analysis. Xiamen Office: 106, Houdaixi Road, Xiamen, China. Orthoperiodic acid can be obtained as a crystalline solid that can be dehydrated to metaperiodic acid, HIO4 (pronounced as "meh-tah-purr-eye-OH-dik"). It is also significant in life science applications as the Periodic Acid-Schiff reaction for the analysis of intracellular polysaccharides like glycogen, starch and cellulose. Chelating agent for metal ions for the stabilisation of oxidising surface cleaners, e.g. Copyright ©2009 Green Stone Swiss Co ., ltd.  All Rights Reserved. Iodine Oxidation State-1 +1 +3 +5 +7; Name. Further heating gives diiodine pentoxide (I2O5) and oxygen rather than the expected anhydride diiodine heptoxide; this anhydride does not occur in nature but can be formed synthetically. Send an Inquiry, get a discount and complete services. Contact us today for more information on any aspect of William Blythe. In dilute aqueous solution, periodic acid exists as discrete hydronium (H3O+) and metaperiodate (IO4−) ions. Periodic acid acts upon the 1,2 glycol linkage (-CHOH -CHOH-) of carbohydrates in tissue sections to produce aldehyde (RCHO+RCHO) which can be colored with Schiff s reagent. . bleach. Shanghai Office: 168 Zhonggu Rd, Pingpu District, Shanghai, China. "Periodic acid" is not derived from "period", but from "iodine": per-iodic acid (compare iodic acid, perchloric acid), and it is thus pronounced per-iodic /ˌpɜr.aɪˈɒdɨk/ PURR-eye-OH-dik, and not as /ˌpɪərɪˈɒdɨk/ PEER-ee-OD-ik. Ideally suited for large-scale automated operations, Selective oxidising agent for stereospecific cleavage of 1,2 glycols. For example, sodium metaperiodate, NaIO4, can be synthesised from HIO4 while sodium orthoperiodate, Na5IO6 can be synthesised from H5IO6. It is also used in organic synthesis as an oxidising agent of moderate strength.